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PD-1 derived CA-170 is an oral immune checkpoint

202168 · Sasikumar et al. describe the identification and characterization of CA-170, a small molecule inhibitor of PD-L1 and VISTA. They find that CA-170 activates T cells

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: Pottayil G. Sasikumar, Naremaddepalli S. Sudarshan, Srinivas Adurthi, Raghuveer K. Ramachandra, Dodd...

CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?

200044 · CA-170 is currently the only small-molecule modulator in clinical trials targeting PD-L1 and VISTA proteins - important negative checkpoint regulators of

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: Bogdan Musielak, Justyna Kocik, Lukasz Skalniak, Katarzyna Magiera-Mularz, Dominik Sala, Miroslawa C...

CA-170 | VISTA/PD-L1 | MCE

CA-170 VISTA PD-L1 。CA-170 PD-L1/L2 VISTA T ,

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PD-1 derived CA-170 is an oral immune checkpoint

202168 · Small molecule immune checkpoint inhibitors targeting PD-1 and other pathways may offer advantages including ease of dosing, ability to manage immune

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CA-170 - Curis, Inc

Preclinical ex vivo data demonstrate that CA-170 can induce effective proliferation and IFN-γ (Interferon-gamma) production -a cytokine that is produced by activated T cells and is a

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2018 ? -

2018101 · 。PD-L1VISTACA170 ,。 2)Car-T

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ESMO 2017 | PD-L1/VISTACA-170 ...

2017912 ·  CA-170 PD-L 1/ VISTA , PD-L1VISTA

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CA-327PD-L1TIM-3。CA170PD-L1VISTA, 1,

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[PDF]

Phase 1 study of CA-170, a first-in-class, orally available,

202213 · dose reduction due to adverse reaction related to CA170. *A total of 5 patients experienced treatment-related adverse events (TRAEs) that were ≥Grade 3: 2

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IND - FDA -

201662 · IND. CA-170. Curis. FDA. :WuXiAppTecChina 15:48. ,Curis,FDA

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CA-170 - Curis, Inc

Preclinical ex vivo data demonstrate that CA-170 can induce effective proliferation and IFN-γ (Interferon-gamma) production -a cytokine that is produced by activated T cells and is a marker of T cell activation- by T cells that are specifically suppressed by PD-L1 or VISTA. In addition, CA-170 also appears to have anti-tumor effects similar to ...

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Inhibition of lung tumorigenesis by a small molecule

2021723 · Pan, Chen, Zhang et al. investigated the anti-cancer efficacy of CA170, a small molecule agonist of VISTA, on mouse lung tumorigenesis. When combined with a MHCII-directed KRAS peptide vaccine ...

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【】ca170ca130, ...

201714 · ca170ca130,. ca,pa,pa190+,ca,。. 324-25,ca190+,,,,,6。. 124,ca170+, ...

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CA170

/ Air China CA170 ,2021 10 30 - (CTS-PEK) CA170,( CTSPEK)。 , “I” 1030 13:50, “3” 1030 17:05。 ...

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[PDF]

Phase 1 study of CA-170, a first-in-class, orally available,

202213 · dose reduction due to adverse reaction related to CA170. *A total of 5 patients experienced treatment-related adverse events (TRAEs) that were ≥Grade 3: 2 patients had lipase increased; 1 pat each of the following: amylase increased, blood bilirubin increased, fatigue, hypokalemia, nausea and vomiting.

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FM2022CA()/PA()_ ...

20211023 · FM2022.. :pa,,, ...

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:PD-L1PPI

20201215 · PDL1. ,,,PD1-PDL1,;

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SF633()____ ...

。. F-(1)。. F-。. ,。. ...

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c1700c1720_

2021821 · 。. C1720。. 、、、、、、。. C1720,。. C1720

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: 5

fm2020ca,2__bilibili

202094 · fm2020ca,2. 2.8 35 14:52:20 ,. 153 70 132 4. ,. . STEAM. . . .

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PD1VISTACT26 ...

BALB/CCT26,,,CA170CA170, ...

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CA-170, a first in class oral small molecule dual inhibitor of

Background: Programmed-death 1 (PD-1) and V-domain Ig suppressor of T-cell activation (VISTA) are independent immune checkpoints that inhibit T cell function. Preclinical studies demonstrated that dual blockade of these checkpoints can be synergistic. CA-170 is an oral small molecule antagonist of PD-L1 and VISTA, currently undergoing Phase (Ph) 1

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Phase 1 trial of CA-170, a novel oral small molecule

2017520 · We found that CA170, a novel orally bioavailable tripeptide small molecule antagonist of VISTA and PD-L1/PD-L2, has potent anticancer efficacy on carcinogen-induced mouse lung tumorigenesis.

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Kate Bush -

,·(Kate Bush),:“?. ,。. ” ,…. 29.

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npc bush people【】_

2019312 · npc bush people. . --. . 12. (:D)∠) ,,. steam. ?.

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() -

2017516 · (). 1. F8/18,。. :RA8(15K)10K8.2K。. ,

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(PDF) -

2015716 · ,, Anti-Adherents, Glidants Lubricants。. 。. 。.

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SY-1365,-16-8-(absin)

SY-1365 is a potent and first-in-class selective CDK7 inhibitor, with a Ki of 17.4 nM. SY-1365 exhibits anti-proliferative and apoptotic effects in solid tumor cell lines. SY-1365 possesses anti-tumor activity in hematological and multiple aggressive solid tumors. Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store ...

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GitHub - DuarteMartinho/CA170: Operating Systems

2022119 · DuarteMartinho/CA170. This commit does not belong to any branch on this repository, and may belong to a fork outside of the repository. master. Switch branches/tags. Branches Tags. Could not load branches. Nothing to show {{ refName }} default View all branches. Could not load tags. Nothing to show

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bush_bush

bush:n.1.;;。2.〔the bush〕〔…,bush、、。"a bird in the bush" : "a nearby bush" : "adapter bush" : "adaptor ...

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(PDF) Inhibition of lung tumorigenesis by a small molecule

2021723 · The combination of CA170 and KVax shows enhanced anti-tumor efficacy in VC-induced lung tumorigenesis A Experimental design outlining the timing of KVax vaccine treatment, CA170 administration ...

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CA-170, a first in class oral small molecule dual inhibitor of

Background: Programmed-death 1 (PD-1) and V-domain Ig suppressor of T-cell activation (VISTA) are independent immune checkpoints that inhibit T cell function. Preclinical studies demonstrated that dual blockade of these checkpoints can be synergistic. CA-170 is an oral small molecule antagonist of PD-L1 and VISTA, currently undergoing Phase (Ph) 1

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Phase 1 trial of CA-170, a novel oral small molecule

2017520 · We found that CA170, a novel orally bioavailable tripeptide small molecule antagonist of VISTA and PD-L1/PD-L2, has potent anticancer efficacy on carcinogen-induced mouse lung tumorigenesis.

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--《 ...

. 【】: N“478”、“CA170”N,,N,2N“478”“CA170 ...

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[fm20] NGA

20111015 ·  2023 2024,ca170 ,0:2 4160+,140+,19186,1.01,

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FM2013CA、PA!【】_

20121017 · FM2013..:1. CA180 PA1832. CA176 PA1863. CA170 PA1824. CA170 PA1755. CA168 PA1806. CA168 FM2013CA、PA!

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() -

2017516 · (). 1. F8/18,。. :RA8(15K)10K8.2K。. ,

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SY-1365,-16-8-(absin)

SY-1365 is a potent and first-in-class selective CDK7 inhibitor, with a Ki of 17.4 nM. SY-1365 exhibits anti-proliferative and apoptotic effects in solid tumor cell lines. SY-1365 possesses anti-tumor activity in hematological and multiple aggressive solid tumors. Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store ...

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GitHub - DuarteMartinho/CA170: Operating Systems

2022119 · DuarteMartinho/CA170. This commit does not belong to any branch on this repository, and may belong to a fork outside of the repository. master. Switch branches/tags. Branches Tags. Could not load branches. Nothing to show {{ refName }} default View all branches. Could not load tags. Nothing to show

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bush_bush

bush:n.1.;;。2.〔the bush〕〔…,bush、、。"a bird in the bush" : "a nearby bush" : "adapter bush" : "adaptor ...

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